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	Provedor de dados Ecology and Society (3) Autor Bennett, Nathan J; Univeristy of British Columbia; Visiting Research Fellow at University of Victoria; nathan.bennett@ubc.ca (1) Beveridge, Rachelle; University of Victoria; rachelle.beveridge@gmail.com (1) Binder, Claudia R.; University of Munich, Germany; claudia.binder@geographie.uni-muenchen.de (1) Cox, Michael E.; Environmental Studies Program, Dartmouth College, New Hampshire; michael.e.cox@dartmouth.edu (1) Epstein, Graham B.; School of Public and Environmental Affairs (SPEA), Indiana University Bloomington; The Vincent and Elinor Ostrom Workshop in Political Theory and Policy Analysis, Indiana University Bloomington; gepstein@indiana.edu (1) Falk, Thomas; University of Marburg, Germany; falkt@staff.uni-marburg.de (1) Fischer, Burnell C.; The Vincent and Elinor Ostrom Workshop in Political Theory and Policy Analysis, Indiana University Bloomington; School of Public and Environmental Affairs (SPEA), Indiana University Bloomington; Center for the Study of Institutions, Population and Environmental Change (CIPEC), Indiana University Bloomington; bufische@indiana.edu (1) Hinkel, Jochen; Global Climate Forum (GCF), Berlin, Germany; hinkel@globalclimateforum.org (1) Klain, Sarah C; University of British Columbia; s.klain.ubc@gmail.com (1) McCord, Paul; Center for the Study of Institutions, Population and Environmental Change (CIPEC), Indiana University Bloomington; Department of Geography, Indiana University Bloomington; The Vincent and Elinor Ostrom Workshop in Political Theory and Policy Analysis, Indiana University Bloomington; pamccord@indiana.edu (1) Mincey, Sarah K.; Integrated Program in the Environment, Indiana University Bloomington; Indiana University Research and Teaching Preserve; Center for the Study of Institutions, Population and Environmental Change (CIPEC), Indiana University Bloomington; The Vincent and Elinor Ostrom Workshop in Political Theory and Policy Analysis, Indiana University Bloomington; School of Public and Environmental Affairs (SPEA), Indiana University Bloomington; skmincey@indiana.edu (1) Vogt, Jessica M.; The Vincent and Elinor Ostrom Workshop in Political Theory and Policy Analysis, Indiana University Bloomington; Department of Earth and Environmental Sciences, Furman University; jessica.vogt@furman.edu (1) Mais... Palavra-chave Social-ecological system framework (3) Benthic fisheries (1) CPR design principles (1) Common-pool resource (1) Common-pool resources (1) Commons (1) Complex commons (1) Ecological theory (1) Environmental governance (1) Forest ecology (1) Indigenous or aboriginal peoples (1) Interdisciplinary science (1) Linked human-natural systems (1) Public good (1) Resource management (1) Resource system (1) Resource unit (1) SES (1) Small-scale fisheries (1) Social-ecological system (1) Mais... Tipo do documento Peer-Reviewed Reports (2) Peer-Reviewed Synthesis (1) Ano 2015 (2) 2014 (1) País Canada (3) Idioma Inglês (3)		Registro completo Provedor de dados:  Biol. Res. País:  Chile Título:  In vivo and in vitro anti-inflammatory activity of Cryptostegia grandiflora Roxb. ex R. Br. leaves Autores:  Castro,Jenny P Ocampo,Yanet C Franco,Luis A Data:  2014-01-01 Ano:  2014 Palavras-chave:  Ear edema Free radicals Inflammation MPO PGE2 RAW 264 7 macrophages Resumo:  BACKGROUND: Despite Cryptostegia grandiflora Roxb. ex R. Br. (Apocynaceae) leaves are widely used in folk Caribbean Colombian medicine for their anti-inflammatory effects, there are no studies that support this traditional use. Therefore, this work aimed to evaluate the effect of the total extract and primary fractions obtained from Cryptostegia grandiflora leaves, using in vivo and in vitromodels of inflammation, and further get new insights on the mechanisms involved in this activity. RESULTS: Ethanolic extract of Cryptostegia grandiflora leaves, and its corresponding ether and dichloromethane fractions, significantly reduced inflammation and myeloperoxidase activity (MPO) in ear tissue of mice treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Histological analysis revealed a reduction of edema and leukocyte infiltration. Complementarily, we demonstrated that extract and fractions reduced nitric oxide (NO•) and prostaglandin E2 (PGE2) production in LPS-stimulated RAW 264.7 macrophages, as well as scavenging activity on DPPH and ABTS radicals. CONCLUSIONS: Our results demonstrated for the first time the anti-inflammatory activity of Cryptostegia grandiflora leaves, supporting its traditional use. This activity was related to inhibition of MPO activity, and PGE2 and NO• production. These mechanisms and its antioxidant activity could contribute, at least in part, to the anti-inflammatory effect showed by this plant. Tipo:  Journal article Idioma:  Inglês Identificador:  http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100032 Editor:  Sociedad de Biología de Chile Formato:  text/html Fonte:  Biological Research v.47 2014 Fechar

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